Final Examination/private Defense for the Degree of Doctor of Philosophy in in the Neuroscience Graduate Program
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چکیده
Cortical dysplasia is a developmental abnormality characterized by changes in the structure and function of the neocortex. This disorder is implicated in many neuropsychiatric disorders such as epilepsy, autism and schizophrenia, and results from failure of immature neurons to appropriately migrate to their cortical targets. We developed a model of cortical dysplasia by administering methylazoxymethanol (MAM), an anti-mitotic, to pregnant ferrets on gestational day 33 leading to abnormal cortical layering, increased expression of GABAA receptors (GABAAR) and altered distribution of neurons derived from the ganglionic eminence (GE). We evaluated the impact of MAM treatment on the kinetic behavior of migrating GE cells and examined the relationship between changes in the ambient level of GABAAR-mediated activity and alterations in neuronal migration
منابع مشابه
Final Examination/private Defense for the Degree of Doctor of Philosophy in the Emerging Infectious Diseases Graduate Program
متن کامل
A Thesis Submitted to the Faculty of Graduate Studies in Partial Fulfilment of the Requirements for the Degree of Doctor of Philosophy Graduate Program in Neuroscience
.............................................................................................................................. ii Acknowledgements ............................................................................................................ iv Dedication .......................................................................................................................... vi T...
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تاریخ انتشار 2012